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When actress Lizzy Caplan starred as Janis Ian in 2004's Mean Girls, she became cemented forever into gay lexicon as the punk bestie we always wanted in high school. Now, as pioneering researcher of human sexuality Virginia Johnson in Showtime's hit series Masters of Sex, she is our new must-watch TV fave. The show follows Johnson and her oft-salacious affairs with fellow researcher Dr. William Masters (Michael Sheen) and the rise of their success — from their humble Midwest beginnings to gracing the cover of Time magazine. Follow Pride for all the latest on the sexy and historical show we can't get enough of!

Masters of Sex Crushes Us with A Lesbian Character Death

Masters of Sex is yet another show to, disappointingly, fall into the "Bury Your Gays" trope. 

INTERVIEW: Master of Sex's Annaleigh Ashford on Playing the Favorite Lesbian Prostitute on TV

Annaleigh Ashford chats exclusively with Shewired about playing Betty DiMello on Masters of Sex, changing lives in Kinky Boots, and returning to Broadway this month.

WATCH: Masters of Sex Taps 'First Kiss' Director for New 'Undress Me' Prom

This promo takes viral video "First Kiss" to the next level when strangers strip down and get snuggly for the first time on camera.

Sarah Silverman Signs On as Masters of Sex's New Lesbian Character

Silverman will play the ex of Annaleigh Ashford's character.

5 Reasons to Plug In to Masters of Sex 

If you missed Masters of Sex, the holidays are a great time to catch up!

Showtime's 'Masters of Sex' Goes Lez

Masters of Sex studies a lesbian prostitute